منابع مشابه
AZT: Unsafe at Any Dose?
html. file:///Users/dad/Documents/Green/AIDS/ARAS/aras.ab.ca ƒ/test/azt-integrated.html (2 of 45)3/27/2006 6:16:14 PM AZT: Unsafe at Any Dose? “1 patient [out of a grand total of 10 in this clinical trial] suffered from severe anemia resulting from ZDV [AZT] therapy” Lafeuillade A et al. Pilot study of a combination of highly active antiretroviral therapy and cytokines to induce HIV-1 remission...
متن کاملAZT as a telomerase inhibitor
Telomerase is a highly specialized reverse transcriptase (RT) and the maintenance of telomeric length is determined by this specific enzyme. The human holoenzyme telomerase is a ribonucleoprotein composed by a catalytic subunit, hTERT, an RNA component, hTR, and a group of associated proteins. Telomerase is normally expressed in embryonic cells and is repressed during adulthood. The enzyme is r...
متن کاملA computational model of mitochondrial AZT metabolism.
The mechanisms of the mitochondrial toxicity of AZT (azidothymidine; zidovudine) are not clear. The two main contenders are the incorporation of phosphorylated AZT into the mtDNA (mitochondrial DNA) and the competitive inhibition of natural deoxynucleotide metabolism. We have built a computational model of AZT metabolism in mitochondria in order to better understand these toxicity mechanisms. T...
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Objective(s):Cutaneous Leishmaniasis (CL) is a parasitic disease caused by various species of the flagellated protozoan, Leishmania. Regardless of the numerous studies, there are still serious challenges in the treatment of CL. This study aimed at evaluating the influence of a low dose ultraviolet B (UVB) radiation along with silver nanoparticles (AgNPs) on a mouse model of CL induced by Leishm...
متن کاملImproving Nurses' Perceived Self-efficacy with Palliative Care Education
Introduction: Due to the remarkable advances in the field of intensive care, it has been possible to assist critically ill patients and this has led to a longer life expectancy in those with very poor prognosis. The purpose of this study was to determine the perceived self-efficacy of nurses with palliative care education. Methods: This study was an experimental study conducted in 2019. The stu...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 1998
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm0298-132a